Thiopurine Calculator

This application allows for the interpretation of drug levels and generates, on the basis of this, individual dosage recommendations in patients with inflammatory bowel disease who use thiopurines.

Publish date: June 2017
Commissioned by: Máxima Pharmaceutical Center

App description

This application allows for the interpretation of drug levels and generates, on the basis of this, individual dosage recommendations in patients with inflammatory bowel disease who use thiopurines. The two main pharmacologically active metabolites of thiopurines are 6-TGN and 6-MMPR. The measured blood plasma level of these metabolites, as well as their mutual ratio, determine the individual dosage recommendation.

This app was developed in collaboration with Dr. L.J.J. Derijks, hospital pharmacist – clinical pharmacologist.

Functionality

By choosing a drug (thiopurines azathiopurine or 6-mercaptopurine and 6-thioguanine) and method of analysis (Lennard, Dervieux, Erdmann), the thiopurine calculator can generate a dosage recommendation for inflammatory bowel disease.